Table 1.
Racial differences in gene expression among white (n = 478) and black (n = 495) women, overall and by breast cancer subtype, from CBCS Phase 3, 2008–2013
| Overall (n = 973) | Luminal A (n = 372) | Basal-like (n = 248) | ||||
|---|---|---|---|---|---|---|
| Gene | Relative expression (95% CI)a | P | Relative expression (95% CI)a | P | Relative expression (95% CI)a | P |
| ACOX2 | 0.99 (0.87–1.12) | 0.849 | 1.00 (0.86–0.96) | 0.958 | 1.12 (0.79–1.58) | 0.539 |
| MUC1 | 0.72 (0.62–0.83) | <0.001 | 0.68 (0.56–0.82) | <0.001 | 0.81 (0.58–1.12) | 0.202 |
| FAM177A1 | 1.00 (0.94–1.06) | 0.941 | 1.00 (0.94–1.07) | 0.962 | 0.98 (0.80–1.20) | 0.834 |
| GSTT2 | 1.41 (1.19–1.68) | <0.001 | 1.43 (1.10–1.85) | 0.008 | 1.58 (1.07–2.32) | 0.020 |
| PSPH | 1.00 (0.91–1.10) | 0.984 | 0.98 (0.88–1.10) | 0.780 | 1.13 (0.87–1.46) | 0.349 |
| PSPHL | 2.38 (2.11–2.67) | <0.001 | 2.33 (1.95–2.79) | <0.001 | 1.77 (1.39–2.24) | <0.001 |
| SQLE | 1.15 (1.04–1.27) | 0.007 | 1.19 (1.05–1.35) | 0.006 | 0.98 (0.76–1.27) | 0.868 |
| TYMS | 1.20 (1.11–1.29) | <0.001 | 1.24 (1.12–1.38) | <0.001 | 1.08 (0.92–1.26) | 0.345 |
RNA counts were normalized log2-transformed prior to analysis
CI confidence interval
aRelative expression comparing black versus white (referent) women; relative expression is adjusted for age, codeset, and PAM50 subtype, as appropriate