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. 2017 Sep 11;37:18. doi: 10.1186/s41232-017-0050-9

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — NLRP3 inflammasome activation mediated by lysosomal destabilization. Various endogenous crystals and exogenous particulate matter activate NLRP3 inflammasomes and cause inflammatory diseases. Phagocytosed particles cause lysosomal destabilization and rupture, which induce the leakage of lysosomal enzyme cathepsin B, resulting in the activation of NLRP3 inflammasomes. As a factor that induces lysosome destabilization, the following crystals or particles are known: MSU crystals, calcium pyrophosphate (CPPD) crystals, cholesterol crystals, silica particles, and β-amyloid