Table 1.

Summary of studies of reprogramming of cancer cells from induce pluripotent stem cell technology. We have modified the summary of the table reported by Camare et al. [25, 26]

CSCs examples	Original cells	Methods of reprogramming	Karyotype	Chimeras	Teratoma/tumor formation	Drug sensitivity
Utikal et al. (2009) [65]	Mice melanoma R454 (rasinduce cells)	Lentivirus OKM	Trisomy chromosomes 8 and 11	Yes	Yes	No tumor in the absence of Dox
Carette et al. (2010) [42]	Human leukemia KBM7 (CML)	Retrovirus OSKM	Tetraployd, chromosomes 9 and 22 Ph(+)	Not applied	Yes	Cell type specific drug sensitivity
		Retrovirus OSK (incomplete reprogramming)
Miyoshi et al. (2010) [43]	Human gastrointestinal cancer cells	Retrovirus and lentivirus + lipofectamine OSKM	Abnormal	Not applied	Yes	Post iPSC cells—more sensitive to 5-Fu and differentiation inducing drug
Kuo et al. (2016) [59]	Human HepG2 liver cancer cells and mouse hepatocytes-iPSCs	Lentivirus OSKM + shp53RNA (lentivirus O + c-JUN for direct reprogramming)	Abnormal	Not applied	Yes	Yes