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. 2017 Oct 2;37:20. doi: 10.1186/s41232-017-0051-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Neuroprotective and neurodegenerative aspects of NO. By activating eNOS (endothelial NO synthase), NO causes neurodegeneration which increases intracellular calcium (Ca²⁺) level following nNOS (neuronal NO synthase) dephosphorylation and oxidative stress. However, iNOS (inducible NO synthase) inhibitors inhibit peroxynitrite anion which halts cytochrome that maintains homeostasis [55]