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. 2017 Dec 7;8:1014. doi: 10.3389/fphys.2017.01014

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Copyright © 2017 Yuan, Tan, Geng, Tan, Chheda and Pandol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CID755673 post-treatment ameliorated the severity of pancreatitis. (A) Blood amylase and lipase activation was decreased in cerulein-induced rat pancreatitis treated with PKD inhibitor CID755673 (CID, 15 mg/kg). (B) Representative H&E-stained pancreatic sections from rat pancreatitis treated without or with CID 755673 compound. Compared to rats without CID755673 treatment, cerulein (CR) induced pancreatitis was greatly ameliorated in rats treated with CID755673 (CID). Edema (C) and the percentage of inflammatory cell infiltration (D) necrosis (E) and number of vacuoles (F) were measured on H&E stained sections. Values are means ± SE (n > 3). ^*p < 0.05, ^**p < 0.01, or #p = 0.054 vs. CR alone without inhibitor pre-treatments.