Table 1.

Overarching objectives of the Strategic Typhoid alliance across Africa and Asia study

Primary	To characterise the burden of enteric fever at three urban sites in Africa and Asia
Secondary	Assess the burden/incidence of enteric fever
	Assess the seroincidence of infection
	Assess host factors affecting burden/incidence/transmission of enteric fever
	Assess effect of pathogen genetics on burden/incidence/transmission of enteric fever
	Develop diagnostic tools for rapid and consistent typhoid diagnosis
	Develop transmission modelling and modelling of vaccine introduction impact
Tertiary objectives	Strengthen research capacity in enteric fever endemic regions
	Provide data to appropriate institutes and governments to advocate vaccine implementation
	To characterise the burden of invasive non-typhoidal salmonellae and other invasive pathogens at an urban site in Malawi, Africa