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Effect of ROS and antioxidants on the activity of osteoclasts, osteoblasts and osteocytes in bone remodeling. ROS activate osteoclast differentiation and osteocyte apoptosis (+), while inhibit osteoblast activity (−) inducing bone resorption; antioxidants activate osteoblast differentiation (+) and inhibit osteoclast activity and osteocyte apoptosis (−) inducing bone formation.
