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CSA inhibits PDH activity in glioblastoma cells. A, CSA and l-cystine lead to a dose-dependent inhibition of PDH activity in U251 (P < 0.007). B, CSA (P < 0.005) but not l-cystine (P = 0.67) inhibits PDH activity in the non-CDO–expressing cell line T98G. C, dichloroacetate (DCA; 1 mmol/L) increases PDH activity in U251 (P = 0.003), which is abrogated with the pretreatment of CSA (1 mmol/L; P = 0.117). Results are representative of at least three independent experiments.
