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. Author manuscript; available in PMC: 2017 Dec 11.
Published in final edited form as: Cancer Res. 2013 Dec 18;74(3):787–796. doi: 10.1158/0008-5472.CAN-13-1423

Figure 4.

Figure 4

CDO modulates glioblastoma growth in vivo. A and B, U251 cells with stable knockdown of CDO1 using shRNA (shCDO; n = 5) or vector control (shControl; n = 5) were injected subcutaneously in a mouse flank model. Tumor growth curves were obtained at stated time points using perpendicular diameter measurements of each tumor with digital calipers and volumes calculated using the formula (L × W × W)/2. B, CDO1 expression determined by Western blot analysis of the indicated tumors grown in the mouse flank model. C, intracanalicular tumors were generated by implanting shCDO (n = 10) or shControl (n = 10) cells. Mice were euthanized once neurologic symptoms became apparent and survival plotted. D, CDO1 expression determined by IHC of the indicated tumors grown in an intracanalicular model.