Table 1.
All | Cases | Non-cases | |||||||
---|---|---|---|---|---|---|---|---|---|
NRI | 95% CI | p | NRI | 95% CI | P | NRI | 95% CI | p | |
NRI>0 | 0.382 | 0.299 to 0.465 | <0.0001 | 0.159 | 0.077 to 0.241 | 0.0001 | 0.223 | 0.210 to 0.235 | <0.0001 |
4-Category | 0.078 | 0.035 to 0.121 | 0.0004 | 0.084 | 0.041 to 0.127 | 0.0001 | −0.006 | −0.011 to −0.002 | 0.0019 |
3-Category | 0.061 | 0.024 to 0.098 | 0.0013 | 0.066 | 0.029 to 0.103 | 0.0004 | −0.006 | −0.009 to −0.002 | 0.0027 |
2-Category | 0.044 | 0.014 to 0.074 | 0.0036 | 0.048 | 0.019 to 0.078 | 0.0014 | −0.004 | −0.007 to −0.002 | 0.0010 |
NRI(p) | 0.005 | −0.020 to 0.030 | 0.69 | −0.007 | −0.031 to 0.017 | 0.56 | 0.012 | 0.008 to 0.016 | <0.0001 |
Cut points for 8-year risk are 0.04, 0.06, and 0.08 for the 4-category NRI (corresponding to 10-year risk of 0.05, 0.075, and 0.10); 0.04 and 0.08 for the 3-category NRI; and 0.06 for the 2-category NRI. The observed 8-year incidence in the sample (p) is 0.023.