Table I.
Two-way ANOVA results with phases T0 vs T1 and treatments as factors (NBR biofeedback, 11 patients; NBR biofeedback+topiramate, 11 patients; topiramate alone, 10 patients)
| Variables Fixed factors |
Pain threshold | R2 area | R2 habituation index | Frequency of headache | MIDAS | Allodynia | TTS | SAS | SDS | SPL9 | Sleep quantity | SF-36 PCS | SF-36 MCS | MAF |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Treatment | ||||||||||||||
|
| ||||||||||||||
| Phase | ||||||||||||||
| T0 vs Tl DF 1 | ||||||||||||||
| F | 0.85 | 4.73 | 3.21 | 4.86 | 10.15 | 1.23 | 0.45 | 0.67 | 1.45 | 0.89 | 1.45 | 14.61 | 3.15 | 5.24 |
| P | n.s. | 0.016 | n.s. | 0.0036 | 0.0004 | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | 0.0001 | n.s. | 0.035 |
|
| ||||||||||||||
| Phase x treatment | ||||||||||||||
| DF 2 | ||||||||||||||
| F | 0.79 | 4.23 | 0.45 | 0.48 | 0.65 | 0.99 | 0.23 | 1.23 | 1.22 | 0.44 | 1.11 | 1.67 | 0.47 | 0.34 |
| P | n.s. | 0.049 | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. |
Abbreviations: MIDAS=Migraine Disability Assessment Scale; TTS=total tenderness score; SAS=self-rating anxiety scale; SDS=self-rating depression scale; SLP9=sleep problems index (Medical Outcomes Study – Sleep Scale sub-item); PCS=Physical Component Summary; MCS=Mental Component Summary; MAF= Multidimensional Assessment of Fatigue. Frequency of headache= average number of days with headache/month computed in the three months preceding T0 and T1 phases)