Table 1. Mean (SD) percentage use of antifibrotics during primary trabeculectomy and phacoemulsification/trabeculectomy.

	1996	2002	2008	2016	p-value
Primary trabeculectomy
MMC	45 (41)	68 (37)	84 (26)	97 (12)	<0.001†
5-FU (IO + PO)	29 (39)	39 (37)	5 (16)	0.8 (6)	<0.001†
5-FU (IO only)	*	23 (33)	3 (10)	0.7 (7)	<0.001†
No antifibrotic	*	*	7 (19)	0.9 (7)	<0.001‡
Phacoemulsification/trabeculectomy
MMC	65 (43)	83 (33)	90 (24)	99 (8)	<0.001†
5-FU (IO + PO)	18 (34)	15 (35)	2 (10)	0.3 (2)	<0.001†
5-FU (IO only)	*	6 (20)	1 (6)	< 0.1	0.009†
No antifibrotic	*	*	6 (21)	1 (8)	0.001‡

5-FU = 5-fluorouracil; IO = intraoperative; MMC = mitomycin C; PO = postoperative; SD = standard deviation.

Data are presented as average percentage (standard deviation of percentage). Percentage in each category may not sum to 100% because of rounding and free-texted responses in the “Other” category for which specific percentage use was not reported.

^*Answer choice not presented in survey.

^†One way analysis of variance (ANOVA) was used to assess the statistical significance of the differences among three means.

^‡Student t-test was used to assess the statistical significance of the difference between two means.