Table 1. Mean (SD) percentage use of antifibrotics during primary trabeculectomy and phacoemulsification/trabeculectomy.
| 1996 | 2002 | 2008 | 2016 | p-value | |
|---|---|---|---|---|---|
| Primary trabeculectomy | |||||
| MMC | 45 (41) | 68 (37) | 84 (26) | 97 (12) | <0.001† |
| 5-FU (IO + PO) | 29 (39) | 39 (37) | 5 (16) | 0.8 (6) | <0.001† |
| 5-FU (IO only) | * | 23 (33) | 3 (10) | 0.7 (7) | <0.001† |
| No antifibrotic | * | * | 7 (19) | 0.9 (7) | <0.001‡ |
| Phacoemulsification/trabeculectomy | |||||
| MMC | 65 (43) | 83 (33) | 90 (24) | 99 (8) | <0.001† |
| 5-FU (IO + PO) | 18 (34) | 15 (35) | 2 (10) | 0.3 (2) | <0.001† |
| 5-FU (IO only) | * | 6 (20) | 1 (6) | < 0.1 | 0.009† |
| No antifibrotic | * | * | 6 (21) | 1 (8) | 0.001‡ |
5-FU = 5-fluorouracil; IO = intraoperative; MMC = mitomycin C; PO = postoperative; SD = standard deviation.
Data are presented as average percentage (standard deviation of percentage). Percentage in each category may not sum to 100% because of rounding and free-texted responses in the “Other” category for which specific percentage use was not reported.
*
Answer choice not presented in survey.
†
One way analysis of variance (ANOVA) was used to assess the statistical significance of the differences among three means.
‡
Student t-test was used to assess the statistical significance of the difference between two means.