Table 2.
Baseline characteristics of study participants with tonometry measurements. Plus minus values are mean ± SD. SpO2 denotes oxygen saturation level as measured by oximetry. MAP = mean arterial pressure, SBP = systolic blood pressure, CF-PWV = Carotid-femoral pulse wave velocity, PP = pulse pressure
| Characteristic | Weight loss (n=48) | CPAP (n=45) | Weight loss + CPAP (n=46) | P value |
|---|---|---|---|---|
| Age - years mean±SD | 49.0±10.7 | 48.9±11.3 | 49.8±12.1 | 0.921 |
| Male sex – no. (%) | 30 (62.5) | 27 (60) | 23 (50) | 0.416 |
| Race – no. (%) | 0.657 | |||
| White | 29 (60.4) | 26 (57.8) | 31 (67.4) | |
| Black | 16 (33.3) | 18 (40) | 14 (30.4) | |
| Mixed or other | 3 (6.2) | 1 (2.2) | 1 (2.2) | |
| Height – cm | 172.6±10.5 | 171.7±9.1 | 171.4±9.4 | 0.826 |
| Weight – kg | 111.4±21.1 | 119.5±21.5 | 112.5±25.2 | 0.180 |
| Waist size - cms | 117.0±14.2 | 124.4±14.3 | 120.5±15.3 | 0.055 |
| Body – mass index | 37.2±4.9 | 40.7±7.5 | 38.1±6.3 | 0.026 |
| Hypertension – no. (%) | 18 (37.5) | 18 (40) | 16 (34.8) | 0.948 |
| Percentage of time SpO2 <90% | 4.2±6.2 | 8.2±15.3 | 6.4±11.6 | 0.262 |
| AHI-events/hr | 38.3±18.5 | 43.1±21.3 | 45.3±26.0 | 0.304 |
| Oxygen desaturation index – no. of events/hour | ||||
| >3% drop from baseline | 22.8±18.2 | 29.1±23.5 | 27.9±26.5 | 0.381 |
| >4% drop from baseline | 18.5±16.3 | 23.9±21.9 | 23.3±25.6 | 0.418 |
| Medication use – no. (%) | ||||
| Statin | 10 (21.3) | 10 (22.2) | 9 (24.3) | 0.951 |
| Antihypertensive | 19 (39.6) | 17 (37.8) | 16 (34.8) | 0.889 |
| Hemodynamics (Mean±SD) | ||||
| Peripheral SBP | 124.8±10.2 | 129.1±10.6 | 128.4±10.2 | 0.099 |
| Peripheral MAP | 96.6±7.6 | 99.3±7.3 | 98.6±7.7 | 0.204 |
| Carotid SBP | 110.6±17.0 | 113.3±14.6 | 113.2±13.8 | 0.624 |
| Carotid MAP | 89.9±9.8 | 92.9±9.6 | 92.2±9.3 | 0.287 |
| Peripheral Augmentation Index | 78.5±16.2 | 74.1±13.5 | 75.5±17.5 | 0.409 |
| Central Augmentation Index | 117.5±32.2 | 116.3±22.5 | 116.2±26.6 | 0.964 |
| CF-PWV | 7.8±1.4 | 8.1±1.7 | 8.2±1.4 | 0.633 |
| Peripheral PP | 46.9±7.6 | 49.7±9.9 | 49.6±7.6 | 0.201 |
| Central PP | 34.8 (14.4) | 34.9 (12.4) | 36.0 (10.6) | 0.892 |