Table I.
Patient characteristics at baseline, treatment initiation, treatment discontinuation, and AH
| Characteristics | All Subjects (N = 28) | Paternal Inheritance (n = 16) | Maternal (n = 9) or Sporadic (N = 2) Inheritance | Unknown Inheritance (n = 1) |
|---|---|---|---|---|
| Initiation of antiandrogen/aromatase inhibitor (baseline) | ||||
| CA (y) | 4.9 ± 1.5 | 4.9 ± 1.5 | 4.8 ± 1.7 | 6.2 |
| BA (y) | 9.7 ± 3.5 | 9.7 ± 3.4 | 9.3 ± 3.8 | 12.5 |
| BA minus CA (y) | 4.8 ± 2.6 | 4.8 ± 2.6 | 4.6 ± 2.7 | 6.3 |
| Predicted AH (cm) | 164.9 ± 10.7§ | 163.7 ± 10.7§ | 166.5 ± 11.7§ | 165.8 |
| Predicted AH (SDS) | −1.7 ± 1.5§ | −1.8 ± 1.5§ | −1.4 ± 1.6§ | −1.5 |
| MPH (cm)* | 177.0 ± 5.3¶ | 175.9 ± 6.3 | 178.5 ± 3.1 | N/A |
| MPH (SDS)* | 0.0 ± 0.7¶ | −0.1 ± 0.9 | 0.2 ± 0.4 | N/A |
| Initiation of GnRHa** | ||||
| CA (y) | 6.9 ± 1.5 | 7.0 ± 1.5 | 6.9 ± 1.6 | 6.6 |
| BA (y) | 12.1 ± 1.6 | 12.2 ± 1.6 | 11.9 ± 1.7 | 13.5 |
| BA minus CA (y) | 5.2 ± 1.9 | 5.3 ± 1.6 | 5.0 ± 2.2 | 6.9 |
| Discontinuation of treatment | ||||
| CA (y) | 12.2 ± 0.5 | 12.2 ± 0.6 | 12.2 ± 0.6 | 12.1 |
| BA (y) | 14.4 ± 1.3 | 14.7 ± 1.5 | 14.0 ± 0.9 | 14.5 |
| BA minus CA (y) | 2.2 ± 1.5 | 2.4 ± 1.7 | 1.8 ± 1.2 | 2.5 |
| Antiandrogen/aromatase inhibitor treatment duration (y) | 7.3 ± 1.8 | 7.3 ± 1.7 | 7.5 ± 2.1 | 5.9 |
| GnRHa treatment duration (y) | 5.3 ± 1.6 | 5.3 ± 1.4 | 5.3 ± 2.0 | 5.5 |
| Predicted AH (cm) | 177.2 ± 9.0 | 176.8 ± 9.9 | 178.5 ± 7.9 | 170.1 |
| Predicted AH (SDS) | 0.1 ± 1.3 | 0.0 ± 1.4 | 0.2 ± 1.1 | −1.0 |
| AH (study end) | ||||
| CA (y) | 16.4 ± 1.3 | 16.6 ± 1.5 | 16.1 ± 0.9 | 15.1 |
| BA (y) | 18.5 ± 0.6 | 18.5 ± 0.4 | 18.5 ± 0.7 | 19.0 |
| AH (cm) | 173.6 ± 6.8 | 172.8 ± 7.4 | 175.4 ± 5.8 | 166.8 |
| AH (SDS) | −0.4 ± 1.0 | −0.5 ± 1.0 | −0.1 ± 0.8 | −1.4 |
CA, Chronological age.
MPH calculation depends on mode of inheritance:
Subjects with maternal or sporadic inheritance: MPH = (father’s height [cm] + mother’s height [cm] + 13 cm)/2
Subjects with paternal inheritance: MPH = (father’s height [cm] + [176.1 cm† − 168.8 cm‡] + mother’s height [cm] + 13 cm)/2
Mean adult male height according to the 2000 National Health Examination Survey.21
Mean paternal height (affected fathers).
Three subjects started treatment at BA too low to determine predicted height (inheritance—2 paternal, 1 maternal).
One subject with unknown inheritance could not be included in these calculations.
One subject (with paternal inheritance) declined treatment with GnRHa.