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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cancer Res. 2017 Dec 1;77(23):6777–6787. doi: 10.1158/0008-5472.CAN-17-1296

Figure 2. Ecological networks among bacterial species associated with EAC or ESCC risk.

Figure 2

The SPIEC-EASI algorithm (33) was used to infer microbial ecological networks. In (a) algorithm was applied to EAC cases and matched controls (n=241), and only networks related to EAC-associated species or a priori periodontal pathogens are shown. In (b) algorithm was applied to ESCC cases and matched controls (n=75), and only networks related to ESCC-associated species or a priori periodontal pathogens are shown. Species associated with EAC or ESCC are colored by phylum; other species in networks are indicated by small gray-outlined circles. Lines connecting species are colored by sign (positive: green, negative: red).