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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cancer Res. 2017 Dec 1;77(23):6777–6787. doi: 10.1158/0008-5472.CAN-17-1296

Figure 3. Correlations of bacterial species and inferred metagenomic functions.

Figure 3

Species and KEGG pathway counts were clr-transformed. Partial Spearman’s correlation coefficients were estimated for each pairwise comparison of species and KEGG pathway abundance, adjusting for age, sex, cohort, race, and smoking. Only KEGG pathways relating to metabolism, and periodontal pathogens or species associated with EAC or ESCC (p<0.05), are included in the heatmap.