Table 4.

Second Malignancies in Patients with Bilateral Retinoblastoma

Tumor type	Patients	Median age at diagnosis (range), years
Total	33	10 (<1–30)
Intracranial
Pineoblastoma	4	0.5 (<1–4)
Primitive neuroectodermal tumor (brain)	1	<1
Sarcoma
Osteosarcoma	13	8 (2–27)
Rhabdomyosarcoma (head/neck)	2	10 (8–12)
Leiomyosarcoma (orbit, bladder)	2	27 (27–27)
Liposarcoma (pelvis)	1	20
Leukemia	3	14 (5–15)
Lymphoma	1	4
Squamous neoplasm (cervix, conjunctiva)	2	18 (14–22)
Adenocarcinoma (cervix)	1	30
Nerve sheath tumor	1	10
Fibrous histiocytoma (sinus)	2	13.5 (12–15)