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. Author manuscript; available in PMC: 2017 Dec 12.
Published in final edited form as: ACS Biomater Sci Eng. 2016 Sep 28;3(2):144–152. doi: 10.1021/acsbiomaterials.6b00422

Figure 4.

Figure 4

Heterogeneous peptide amphiphile micelles induced strong IgG1 and IgG3 antibody subtype responses in vivo. The strong IgG response induced by J8 peptide in IFA or J8-diC16 vaccines was found to be predominantly comprised of the IgG1 subtype. Heterogeneous micelles, on the other hand, produced a different antibody response than the controls comprised mostly of IgG1 with some IgG3 and a small amount of IgG2a. The modular addition of adjuvants has therefore allowed for the immune response to be controlled. Also, no mouse produced above background levels of IgG4 titers. Each point represents one mouse (N = 5); bars represent the geometric mean. Within a graph, groups that possess different letters have statistically significant differences in mean (p ≤ 0.05) whereas those that possess the same letter are similar (p > 0.05).