Extended Data Figure E7. Activity window of late-stage ABEs.

a, Relative A•T to G•C base editing efficiencies in HEK293T cells of late-stage ABEs at protospacer positions 1–9 in two human genomic DNA sites that together place an A at each of these positions. Values are normalized to the maximum observed efficiency at each of the two sites for each ABE = 1. b, Relative A•T to G•C base editing efficiencies in HEK293T cells of late-stage ABEs at protospacer positions 1–18 and 20 across all 19 human genomic DNA sites tested. Values are normalized to the maximum observed efficiency at each of the 19 sites for each ABE = 1. For (a) and (b), values and error bars reflect the mean and s.d. of three independent biological replicates performed on different days.