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. Author manuscript; available in PMC: 2018 Apr 25.
Published in final edited form as: Nature. 2017 Oct 25;551(7681):464–471. doi: 10.1038/nature24644

Extended Data Figure E8. Rounds of evolution and engineering increased ABE processivity.

Extended Data Figure E8

The calculated mean normalized linkage disequilibrium (LD) between nearby target As at 6 to 17 human genomic target DNA sites for the most active ABEs emerging from each round of evolution and engineering. Higher LD values indicate that an ABE is more likely to edit an A if a nearby A in the same DNA strand (the same sequencing read) is also edited. LD values are normalized from 0 to 1 in order to be independent of editing efficiency. Values and error bars reflect the mean and s.d. of normalized LD values from three independent biological replicates performed on different days.