Table 3.
Neurodevelopmental outcomes at 22–26 month corrected age follow up
| HOX N= 74 |
LOX N= 62 |
P Value |
|
|---|---|---|---|
| Age at follow up assessment, months, median (interquartile range) | 23 (22,24) | 24 (22,25) | NS |
| Cerebral Palsy, n (%) | 8 (11%) | 5(8%) | NS |
| GMFCS score ≥2, n (%) | 6 (8%) | 1 (2%) | NS |
| Vision impairment, n (%) | 4 (5%) | 0 | NS |
| Permanent Deafness, n (%) | 2 (3%) | 2 (3%) | NS |
| Need hearing aid, n (%) | 4 (5%) | 0 | NS |
| Bayley III cognitive composite score, median (interquartile range) | 85 (75,90) | 85 (80,95) | NS |
| Bayley III motor composite score, median (interquartile range) | 88 (76,94) | 91 (85,97) | 0.01 |
| Bayley III language composite score, median (interquartile range) | 79 (71,86) | 83 (74,90) | NS |
| Neurodevelopmental impairment, n (%) | 41 (55%) | 25 (40%) | NS |
| Modified neurodevelopmental impairment† n (%) | 32 (43%) | 21 (34%) | NS |
| Severe neurodevelopmental impairment, n (%) | 13 (18%) | 3 (5%) | 0.04 |
| HOX N=110* | LOX N=89* | ||
| Death before follow up assessment‡, n (%) | 21 (19%) | 17 (19%) | NS |
| NDI or Death*, n (%) | 62 (54%) | 42 (47%) | NS |
| Severe NDI or Death*, n (%) | 34 (31%) | 20 (22%) | NS |
†
Modified NDI was calculated with Bayley III motor composite score cut off <73 instead of <85 as used in NDI definition
‡
One infant died in HOX group after discharge from NICU. No death in LOX group after discharge from NICU
*
For primary outcome, denominator changed to total study population