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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2016 Dec 23;66(5):979–996. doi: 10.1111/rssc.12204

Table 5.

Application of the proposed CPP design to the biosimilar trial of Humira

Scenario Clinical Response
 Power
 Sample Size
Humira Test agent CPP NB CPP NB
1 0.608 0.608 81% 67% 190 188
2 0.486 0.486 76.4% 74.4% 256 259
3 0.608 0.486 4.3% 4.6% 140 137