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. 2017 Dec 12;12(12):e0189528. doi: 10.1371/journal.pone.0189528

Fig 3. CSS drastically impairs in vitro angiogenesis.

Fig 3

(A) Representative images of spheroids from F-ECs (upper panels) or M-ECs (lower panels) embedded in collagen gels in the presence of SM (left panels) or CSS-M (right panels). Photographs were taken 24 h later. Quantification of the cumulative length (B), the average length (C), and the number of sprouts (D) emerging from F- or M-EC spheroids incubated in the presence of SM (solid bars) or CSS-M (open bars). *p<0.05, **p<0.01, ***p<0.001 vs SM; §p<0.05vs F-ECs cultured in CSS-M, n = 7, t test. F- and M-ECs are orange and blue, respectively.