Fig 3. ¹⁶O TBI caused the reduction of the clonogenic function in HPCs and HSCs.

(A) BM-MNCs were isolated from irradiated and non-irradiated (CTL) mice three months after ¹⁶O TBI and a CFU assay was performed. Results are presented as mean CFUs per 1x10⁵ BM-MNCs (n = 5). (B) Total BM cells (BMCs) were analyzed by CAFC assays, and the numbers of five-week CAFCs are expressed as means ± SD (n = 3 mice per group) per 1x10⁵ BMCs. The statistical significance for differences between the control group and each of the irradiated groups is indicated by asterisks. *p<0.05, **p<0.01 as determined by one-way ANOVA, followed by Tukey-Kramer test for individual comparisons.