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. 2017 Dec 12;12(12):e0189330. doi: 10.1371/journal.pone.0189330

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© 2017 Stujanna et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — Flow cytometric analysis of the infiltration of inflammatory cells into the infarct and border areas at 1 day after myocardial infarction (MI) (n = 5 in each group). The representative plots (gated on CD45+ and expanded into Ly6G and CD11b) of (A) Sham+V, (B) MI+V, and (C) MI+SR9009 are shown. (D) The percentage of CD45+CD11b+Ly6G+ cells (neutrophils) to CD45+ cells was significantly lower in MI+SR than in MI+V, suggesting that neutrophil infiltration was reduced by SR9009 treatment. Flow cytometric analysis of M1/M2 macrophage infiltration into the infarct and border areas at 5 days after MI (n = 5 in each group). The representative plots (gated on CD11b and expanded into F4/80 and CD206) of (E) MI+V, and (F) MI+SR9009 are shown. (G) The percentage of F4/80+CD206- cells to live cells was significantly lower in MI+SR than in MI+V although the percentage of F4/80+CD206+ cells to live cells was not significantly different between MI+V and MI+SR, suggesting that proinflammatory M1 macrophage infiltration was reduced by SR9009 treatment. The bar graphs show the group mean±SEM. *p<0.05 vs Sham+V; †p<0.05 vs MI+V.