Table 1. Tissue weights and echocardiographic parameters.
| Sham+V | Sham+SR | MI+V | MI+SR | |
|---|---|---|---|---|
| n = 4 | n = 4 | n = 9 | n = 7 | |
| BW | 24.02±0.62 | 25.35±0.23 | 23.77±0.75 | 23.39±0.83 |
| Heart | 125.8±2.45 | 139.45±6.55 | 157.38±9.42* | 148.97±13.46 |
| HW/BW | 5.24±2.45 | 5.49±0.24 | 6.78±0.46* | 6.30±0.40 |
| LV/BW | 4.29±0.05 | 4.44±0.15 | 5.42±0.36* | 5.35±0.51* |
| Lung/BW | 5.38±0.21 | 5.19±0.13 | 8.25±1.08* | 7.20±0.87* |
| LVDd (mm) | 3.16±0.19 | 2.78±0.24 | 5.25±0.21* | 4.88±0.26* |
| LVDs (mm) | 2.13±0.23 | 1.87±0.30 | 4.97±0.24* | 4.36±0.30* |
| FS (%) | 31.67±4.74 | 32.29±4.10 | 6.23±0.92* | 11.07±2.04*† |
| EF (%) | 64.67±7.66 | 61.71±6.27 | 13.85±2.02* | 23.78±4.21*† |
| IVST (mm) | 0.725±0.02 | 0.69±0.11 | 0.67±0.06 | 0.74±0.03 |
| PWT (mm) | 0.62±0.10 | 0.90±0.07 | 0.68±0.04 | 0.60±0.11 |
| LV Mass (mg) | 83.12±12.11 | 85.72±11.72 | 156.02±21.33* | 147.30±11.64* |
LV ejection fraction (EF) and fractional shortening (FS) were significantly higher in MI+SR than in MI+V, whereas LV end-diastolic diameter (LVDd), LV end-systolic diameter (LVDs) and LV mass were not significantly different between MI+V and MI+SR, and the ratios of heart weight to BW, left ventricular (LV) weight to BW, and lung weight to BW were also not significantly different between MI+V and MI+SR (n = 4 in each sham group, n = 9 animals in MI+V group, and n = 7 animals in MI+SR group). The bar graphs show the group mean±SEM.
*p<0.05 vs Sham+V
†p<0.05 vs MI+V