Fig. 2.

Medial thickening of the cultured human saphenous vein is modulated by TREM-1 signaling. Human saphenous vein (HSV) explants were subjected to ex vivo culture for 7 days with or without a synthesized human TREM-1 inhibitory peptide (hLP17) or a monoclonal TREM-1-specific activating antibody (Ab). (A) Shown are representative images of HSV sections with immunostaining for α-smooth muscle actin (brown). (B) Quantification of intimal, medial and adventitial thickness. Data are expressed as mean±SD of 4 independent experiments. *p<0.05, **p<0.01 versus control.