Table 1. Demographic characteristics of study patients according to degree of white matter hyperintensity (WMH).
| Total | Severe WMH | No or mild WMH | p-value | |
|---|---|---|---|---|
| n = 538 | n = 243 | n = 295 | ||
| Age, years | ||||
| mean ± SD | 65.7 ± 10.3 | 69.6 ± 8.3 | 62.5 ± 10.7 | |
| median | 67.0 [59.0–73.0] | 69.0 [64.0–75.0] | 63.0 [55.0–70.0] | <0.001 |
| <65 | 233 (43.3) | 68 (28.0) | 165 (55.9) | |
| ≥65 | 305 (56.7) | 175 (72.0) | 130 (44.1) | |
| Sex, men | 361 (67.1) | 152 (62.6) | 209 (70.8) | 0.042 |
| Hypertension | 416 (77.3) | 202 (83.1) | 214 (72.5) | 0.004 |
| Diabetes | 221 (41.1) | 98 (40.3) | 123 (41.7) | 0.749 |
| Hyperlipidemia | 68 (12.6) | 28 (11.5) | 40 (13.6) | 0.479 |
| Smoking | 268 (49.8) | 106 (43.6) | 162 (54.9) | 0.009 |
| Pulse pressure (mmHg) | 71.1 ± 20.6 | 73.3 ± 21.6 | 69.4 ± 19.6 | 0.034 |
| Total cholesterol (mmol/L) | 4.7 ± 1.0 | 4.7 ± 0.9 | 4.7 ± 1.0 | 0.725 |
| Triglyceride (mmol/L) | 1.5 ± 0.8 | 1.4 ± 0.7 | 1.6 ± 0.9 | 0.001 |
| HDL (mmol/L) | 1.1 ± 0.4 | 1.1 ± 0.4 | 1.1 ± 0.4 | 0.284 |
| LDL (mmol/L) | 2.8 ± 1.0 | 2.9 ± 1.0 | 2.8 ± 1.1 | 0.136 |
| Serum creatinine (μmol/L) | 1.0 ± 0.6 | 1.0 ± 0.6 | 1.0 ± 0.6 | 0.602 |
| Initial NIHSS score | 4.0 [2.0–8.25] | 4.0 [2.0–9.0] | 4.0 [2.0–8.0] | 0.752 |
| 0–2 | 195 (36.2) | 93 (38.3) | 102 (34.6) | |
| 3–5 | 133 (24.7) | 56 (23.0) | 77 (26.1) | |
| ≥6 | 210 (39.0) | 94 (38.7) | 116 (39.3) | |
| Previous antithrombotics | 40 (7.4) | 18 (7.4) | 22 (7.5) | 0.982 |
| Antiplatelet | 37 (6.9) | 16 (6.6) | 21 (7.1) | 0.807 |
| Anticoagulant | 4 (0.7) | 3 (1.2) | 1 (0.3) | 0.332 |
| Previous statin | 24 (4.5) | 11 (4.5) | 13 (4.4) | 0.947 |
Data are expressed as the mean ± SD, median [interquartile range], or number (%);
HDL, high density lipoprotein; LDL, Low density lipoprotein; NIHSS, National Institute of Health Stroke Scale.