Table 2. Univariable and multivariable analyses for poor outcome at 3 months (mRS 3–6).

	Univariable		Multivariable
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)
<65	1
≥65	1.20 (0.83–1.74)	0.342	1.12 (0.69–1.80)	0.649
Sex (men)	0.89 (0.60–1.31)	0.544	1.21 (0.75–1.97)	0.438
Hypertension	1.63 (1.02–2.61)	0.041	1.52 (0.86–2.68)	0.149
Diabetes	1.10 (0.76–1.60)	0.616
Hyperlipidemia	1.11 (0.64–1.91)	0.720
Smoking	0.94 (0.65–1.36)	0.751
Pulse pressure (mmHg)	1.00 (1.00–1.01)	0.415
Total cholesterol (mmol/L)	1.13 (0.93–1.37)	0.213
Triglyceride (mmol/L)	0.78 (0.60–1.01)	0.057	0.82 (0.62–1.10)	0.190
HDL (mmol/L)	1.54 (0.95–2.48)	0.078	1.67 (0.95–2.93)	0.076
LDL (mmol/L)	1.03 (0.86–1.23)	0.789
Serum creatinine (μmol/L)	0.96 (0.69–1.33)	0.791
Initial NIHSS score
0–2	1		1
3–5	6.02 (2.75–13.17)	<0.001	6.08 (2.75–13.48)	<0.001
≥6	30.39 (14.74–62.66)	<0.001	30.95 (14.82–64.66)	<0.001
Previous antithrombotics	1.11 (0.56–2.20)	0.773
Previous statin	1.15 (0.48–2.74)	0.756
Severe WMH	1.23 (0.85–1.78)	0.265	1.17 (0.73–1.86)	0.525

Data are expressed as the hazard ratio (95% CI);

HDL, high density lipoprotein; LDL, Low density lipoprotein; NIHSS, National Institute of Health Stroke Scale; WMH, white matter hyperintensity.