Table 3. Cox regression analysis of long-term mortality.

	Univariable		Multivariable
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)
<65	1		1
≥65	2.96 (2.15–4.10)	<0.001	2.91 (2.05–4.12)	<0.001
Sex (men)	1.26 (0.93–1.72)	0.141	0.84 (0.61–1.15)	0.836
Hypertension	0.90 (0.65–1.24)	0.504
Diabetes	1.30 (0.98–1.71)	0.067	1.48 (1.11–1.97)	0.007
Hyperlipidemia	0.84 (0.54–1.31)	0.450
Smoking	1.00 (0.76–1.32)	0.984
Pulse pressure (mmHg)	1.00 (0.99–1.62)	0.368
Total cholesterol (mmol/L)	0.99 (0.85–1.14)	0.847
Triglyceride (mmol/L)	0.78 (0.64–0.96)	0.017	0.92 (0.76–1.12)	0.397
HDL (mmol/L)	1.19 (0.85–1.65)	0.317
LDL (mmol/L)	1.02 (0.89–1.17)	0.761
Serum creatinine (μmol/L)	1.50 (1.33–1.69)	<0.001	1.37 (1.21–1.56)	<0.001
Initial NIHSS score
0–2	1		1
3–5	1.85 (1.25–2.75)	0.002	2.15 (1.43–3.23)	<0.001
≥6	2.73 (1.93–3.87)	<0.001	3.14 (2.18–4.52)	<0.001
Previous antithrombotics	1.09 (0.62–1.91)	0.771
Previous statin	0.67 (0.27–1.62)	0.368
Severe WMH	1.65 (1.25–2.18)	<0.001	1.50 (1.12–2.00)	0.007

Data are expressed as the hazard ratio (95% CI);

HDL, high density lipoprotein; LDL, Low density lipoprotein; NIHSS, National Institute of Health Stroke Scale; WMH, white matter hyperintensity.