Fig. 2.

Percent infarct size assessed 120 min after global IR injury when the same (Fig. 1) isolated guinea pig hearts were perfused without ischemia (Time Controls, TC); with 35 min ischemia and 120 min reperfusion (IR); or with IR + BK_Ca and or SK_Ca channel agonists (A); IR + BK_Ca and or SK_Ca channel antagonists (B); IR + BK_Ca agonist and or BK_Ca, SK_Ca antagonists (C); IR + BK_Ca agonist and or SK_Ca or BK_Ca antagonist (D); and SOD dismutator + BK_Ca and or SK_Ca agonist (E). Representative hearts from 4 groups displaying normal and infarcted tissue are displayed (F). Note the enhanced infarct size after treatment with BK_Ca or BK_Ca + SK_Ca antagonists (green bars) vs. IR only (red bars); the block of tissue protection by the BK_Ca or SK_Ca agonists when the BK_Ca or SK_Ca antagonists, respectively, was present (green bars); the maintained reduction in infarct size by the BK_Ca and or SK_Ca agonists in the presence of either the SK_Ca or the BK_Ca antagonist, respectively, (blue bars); and the loss of protection by the SK_Ca and or BK_Ca agonists in the presence of SOD inhibition by TBAP (orange/green bars). For each treatment and control group n=4. *^,§P<0.05.