Figure 7.

MeHg-induced potentiation of I_GABA mediated by both subtype receptors is sensitive to block by the GABA_A receptor antagonist bicuculline. Left, whole cell currents were recorded from a representative oocyte expressing recombinant α₁β₂γ_2S containing receptors ar a holding potential of −60 mV. Currents were recorded before (control), at 35 min (T35) in the presence of 5 μM MeHg, at 60 min (T60) in the presence of both 5 μM MeHg and 20 μM bicuculline and 65 min again in the presence of MeHg alone. Right, whole cell currents were recorded from a representative oocyte expressing recombinant α₆β₂γ_2S receptors under similar conditions as for α₁β₂γ_2S receptors, but with different time points.