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. Author manuscript; available in PMC: 2017 Dec 12.
Published in final edited form as: Neurotoxicology. 2016 Oct 6;60:161–170. doi: 10.1016/j.neuro.2016.10.003

Figure 8.

Figure 8

MeHg caused an increase in outward currents in the water-injected oocytes. A family of whole cell currents was recorded from a water-injected oocyte at a holding potential of −60 mV before (A) and after exposure to MeHg for 10 (B), 20 (C) and 25 min (D). Treatment with niflumic acid (NA, 300 μM) (B) for 5 min, a Ca2+-activated chloride channel blocker, caused a significant decrease in MeHg-induced outward currents (E). Effect of MeHg and NA on whole cell current-voltage relationships are shown in F. Clearly, MeHg increased both inward and outward currents, but primarily so outward currents. Each trace is a representative depiction of 5 individual experiments.