Table 1.
Variables Associated with t-PA Sensitivity
| nHS | HS | P Value | |
|---|---|---|---|
| Male (n=398) | 79% | 81% | 0.631 |
| Age (n=398) | 33 (26–48) | 34 (26–49) | 0.069 |
| Penetrating (n=398) | 51% | 32% | <0.001 |
| NISS (n=386) | 16 (12–39) | 34 (14–54) | <0.001 |
| ED SBP (n=397) | 110 (90–138) | 100 (79–136) | 0.002 |
| ED GCS (n=394) | 15 (10–15) | 10 (3–10) | <0.001 |
| Lactate (n=244) | 3.6 (2.7–5.1) | 4.9 (2.8–8.5) | 0.001 |
| Ph (n=304) | 7.3 (7.2–7.4) | 7.2 (7.1–7.3) | <0.001 |
| BD (n=304) | 8 (5–12) | 10 (7–16) | <0.001 |
| Hb (n=391) | 13.6 (12.3–14.9) | 12.6 (10.9–14.8) | <0.001 |
| Plt Count (n=391) | 265 (188–329) | 206 (129–260) | <0.001 |
| ADP Plt Function MA (n=305) | 47 (31–57) | 25 (13–36) | <0.001 |
| INR (n=385) | 1.19 (1.10–1.39) | 1.37 (1.15–1.74) | <0.001 |
| Fibrinogen (n=110) | 206 (157–262) | 155 (126–207) | 0.001 |
| D-Dimer (n=100) | 2.7 (0.5 – 6.6) | 8.6 (1.7–20.1) | 0.001 |
| R-TEG ACT | 121 (113–128) | 121 (113–144) | 0.114 |
| R-TEG Angle | 72 (67–75) | 67 (60–72) | <0.001 |
| R-TEG MA | 64 (59–68) | 56 (48–62) | <0.001 |
| R-TEG LY30 | 1.8 (1.0–2.9) | 1.9 (0.9–3.8) | 0.349 |
t-TEG= t-PA challenge TEG, r-TEG= rapid TEG, nHS= non hypersensitive ; HS= t-PA hypersensitive; SD = shutdown; PY = physiologic; HY = hyperfibrinolysis.