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. Author manuscript; available in PMC: 2017 Dec 12.
Published in final edited form as: Cell Rep. 2017 Dec 5;21(10):2829–2841. doi: 10.1016/j.celrep.2017.11.033

Figure 7. Model elucidating the role of MELK in melanoma.

Figure 7

Activated MAP kinase signaling pathway leads to the upregulation of MELK expression via the transcription factor E2F1. MELK in turn phosphorylates the adapter protein SQSTM1, which stimulates NF-κB pathway activity, which is necessary for stimulating melanoma growth.