Table 1.

Critical appraisal of the Source CPGs by the Appraisal of Guidelines for Research & Evaluation II (AGREE II) Instrument.

CPGs AGREE-II domains scores (%)	Texas 2009	NICE 2012	NCS 2012	AES 2016
Domain 1: Scope & Purpose	92	100	78	100
Domain 2: Stakeholder Involvement	47	100	41	44
Domain 3: Rigour of Development	56	98	68	69
Domain 4: Clarity & Presentation	100	97	80	92
Domain 5: Applicability	48	85	10	21
Domain 6: Editorial Independence	50	88	19	38
Overall Assessment (%)	85	100	57	75
Recommendation for CPG use	Yes - 1, Yes with modifications - 1, No - 0	Yes - 1, Yes with modifications - 1, No - 0	Yes - 1, Yes with modifications - 0, No - 1	Yes - 1, Yes with modifications - 1, No - 0

The overall assessment and decision of the CPG Adaptation working group, based on the AGREE-II domain scores, was to adapt the NICE CPG and exclude the Texas, NCS, and AES CPGs. CPGs: Clinical Practice Guidelines, AGREE: Appraisal of Guidelines for Research and Evaluation, Texas: Texas Children’s Hospital Evidence-Based Outcomes Center, NICE: National Institute for Health and Care Excellence, NCS: Neurocritical Care Society, AES: American Epilepsy Society