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. 2017 Dec 9;13:27–31. doi: 10.1016/j.bbrep.2017.11.005

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Interactions between M116, CCL17 and its receptor CCR4. (A) Crystal structure of the CCL17-M116 complex. (B) A model of the CCL17-M116 dimer based on the structures of monomeric CCL17-M116 complex and free CCL17 dimer (PDB entry 1nr4) [16]. (C) A model of CCL17-CCR4-M116 ternary complex. The model was obtained by superposition of the CCL17-M116 structure on the CXCR4-vMIP-II structure (PDB entry 4rws) [24]. CCL17 is in orange/yellow, Fab light chain in cyan, Fab heavy chain in blue.