Table 1.
Summary of HCV-3 Trials and Rates of SVR12
| Trial Name | Regimen | Tx Duration (weeks) | SVR12 for Treatment Naïve, Non-cirrhotic (%) | SVR12 for Treatment Naïve, Cirrhotic (%) | SVR12 for Treatment Experienced, Non-cirrhotic (%) | SVR12 for Treatment Experienced, Cirrhotic (%) |
|---|---|---|---|---|---|---|
| FUSION | SOF+RBV | 12 | 37 | 19 | -- | -- |
| SOF+RBV | 16 | 63 | 61 | -- | -- | |
| POSITRON | SOF+RBV | 12 | 68 | 21 | -- | -- |
| VALENCE | SOF+RBV | 24 | 95 | 92 | 87 | 62 |
| BOSON | SOF+RBV | 16 | 83 | 57 | 76 | 47 |
| 24 | 90 | 82 | 81 | 76 | ||
| ALLY-3 | DAC+SOF | 12 | 90 | 58 | 86 | 69 |
| ALLY-3+ | DAC+SOF+RBV | 12 | 100 | 88 | -- | 93 |
| 16 | 100 | 89 | -- | 86 | ||
| ASTRAL-3 | SOF+VEL | 12 | 98 | 91 | 93 | 89 |