Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Anesthesiology. 2018 Jan;128(1):117–129. doi: 10.1097/ALN.0000000000001926

Figure 2.

Figure 2

Isoflurane preconditioning elevated the expression of microRNA-21 associated with cardioprotective effect in C57BL/6 mice but decreased microRNA-21 in db/db mice. A: alterations in microRNA-21 by isoflurane in C57BL/6 and db/db mice (mean ± SD, n=8 mice/group); B: isoflurane improved +dP/dt (the maximum rate of left ventricular developed pressure increase) in C57BL/6 but not microRNA-21 knockout mice 2 h after reperfusion (reperfusion) (n=9 mice in control, 8 mice in microRNA-21 knockout group, 9 mice in isoflurane group, and 7 mice inmicroRNA-21 knockout+isoflurane group); C: isoflurane improved the values of -dP/dt (the maximum rate of left ventricular developed pressure decrease) in C57BL/6 but not microRNA-21 knockout mice 2 h min after reperfusion (n=9 mice in control, 8 mice in microRNA-21 knockout group, 9 mice in isoflurane group, and 7 mice inmicroRNA-21 knockout+isoflurane group). Control, C57BL/6 mouse hearts undergoing ischemia/reperfusion injury: db/db, db/db mouse hearts undergoing ischemia/reperfusion injury; microRNA-21 knockout, microRNA-21 knockout mouse hearts subjected to ischemia/reperfusion injury; isoflurane, C57BL/6 mouse hearts treated with 1.4% isoflurane before ischemia; db/db+isoflurane, C57BL/6 mouse hearts treated with isoflurane before ischemia; microRNA-21 knockout+isoflurane, microRNA-21 knockout mouse hearts treated with isoflurane prior to ischemia. *P<0.05 versus control groups, †P<0.05 versus db/db or microRNA-21 knockout groups, #P<0.05 versus isoflurane groups.