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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Anesthesiology. 2018 Jan;128(1):117–129. doi: 10.1097/ALN.0000000000001926

Figure 4.

Figure 4

Effects of diabetes and isoflurane treatment on the levels of reduced form of nicotinamide adenine dinucleotide during ischemia and reperfusion. All hearts were stabilized in Langendorff apparatus for 30 minutes (baseline) and perfused with the buffer with or without isoflurane prior to 30 minutes of global ischemia (ischemia) followed by 2 h of reperfusion (reperfusion). Control, C57BL/6 mouse hearts undergoing ischemia/reperfusion injury: db/db, C57BL/6 mouse hearts undergoing ischemia/reperfusion injury; isoflurane, C57BL/6 mouse hearts treated with 1.4% isoflurane before ischemia; db/db+isoflurane, db/db mouse hearts treated with 1.4% isoflurane before ischemia. *P<0.05 versus control groups, †P<0.05 versus db/db groups, #P<0.05 versus isoflurane groups (n=9 mice in control, 8 mice in db/db group, 9 mice in isoflurane, and 8 mice in db/db+isoflurane group).