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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Microbes Infect. 2017 Sep 9;19(12):626–634. doi: 10.1016/j.micinf.2017.08.013

Figure 3. Blockage of Treg in aged mice enhances induction of IgG but not IgM antibodies against influenza virus PR8 HA.

Figure 3

Groups aged mice (6 per group, 18-month old) were immunized twice at 4-week intervals by different immunization regimens as shown in Fig. 2. Blood samples were collected at 2 weeks after the second immunization and analyzed for antibody responses against the HA of influenza virus PR8. The levels of antibody responses against HA were determined by ELISA using purified HA proteins as coating antigens, and expressed as the amount of HA-specific antibodies IgG or IgM in 1 ml of serum samples (ng/ml). Error bars indicate standard deviations for each group. (A). IgG antibody levels against the influenza virus PR8 HA. (B). IgM antibody levels against the influenza virus PR8 HA. Data are presented as the mean ± standard deviation. (*) indicate significantly higher compared to Group NT (p<0.01) and (**) indicate significantly higher compared to Group P or Group B (p<0.05).