Skip to main content
. Author manuscript; available in PMC: 2018 May 27.
Published in final edited form as: Nat Chem Biol. 2017 Nov 27;14(1):65–71. doi: 10.1038/nchembio.2520

Figure 4. Compounds 10 and 11 inhibit Notch-Dll ligand binding.

Figure 4

Notch ligand binding experiments were performed to measure the effect of fucose analogs on the ability of mNotch1 (a–c) or mNotch2 (d–f) transfectants to bind soluble Dll1-Fc (a, d), Dll4-Fc (b, e), or Jag1-Fc (c, f) using cell-based flow cytometry assays. EV transfected cells were used as a negative control and cells cultured in the presence of DMSO served as a positive control. Six independent experiments were performed for all samples (n=6). All plots represent mean ± SEM. *p<0.05, **p<0.01, ***p<0.001, Tukey post-hoc test, adjusted p values.