Figure 9.

Cytokeratin staining of serial sections through a 9.5-week human fetal clitoris grown for 14 days in an untreated castrated host. Top, A–C, approximate section levels: Distal (A), mid-shaft (B) and proximal (C) transverse sections stained for K6 and K7. K6 is expressed in the vestibular plate, in basal cells of the surface epidermis and in basal layers of the vestibular groove of the graft. K7 is present only in apical layers of the dorsal aspect of the vestibular groove as in non-grafted clitoral specimens (Fig. 8). Bottom, D–F, approximate section levels: Distal (D), mid-shaft (E) and proximal (F) sections through the same xenograft stained with K6 and K10. K6 is expressed as above. K10 is present in apical cells of the surface epidermis, the lateral and ventral aspects of the vestibular groove and is absent in the dorsal aspect of the vestibular groove as is seen in non-grafted clitoral specimens.

Gross 10-week human fetal clitoral specimen showing approximate levels of post-grafting histologic sections.