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. 2017 Dec 8;9:383. doi: 10.3389/fnagi.2017.00383

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Copyright © 2017 Ianov, De Both, Chawla, Rani, Kennedy, Piras, Day, Siniard, Kumar, Sweatt, Barnes, Huentelman and Foster.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Performance on the water maze task. Symbols indicate the mean (±SEM) escape path length to the escape platform during 5 training blocks on the (A) cue and (B) spatial discrimination tasks for young (open symbols) and aged (filled symbols) animals. (C) Acquisition of a spatial search strategy. Individual discrimination index scores for young (open symbols) and aged (filled symbols) animals. The dashed line indicates the cut-off for behavioral classification of aged-impaired (AI) and aged-unimpaired (AU) animals.