Table 3.
Genes of age impaired and age unimpaired animals, which were significantly differentially expressed in region CA1 in both the Illumina and Ion Proton data.
| Gene symbol | Gene Name | Ca2+ binding | Synaptic function |
|---|---|---|---|
| Adra1d | Adrenergic, alpha-1D-, receptor | x | x |
| Akap13 | A kinase (PRKA) anchor protein 13 | x | |
| Arpc5 | Actin related protein 2/3 complex, subunit 5 | x | |
| Dclk2 | Doublecortin-like kinase 2 | x | |
| Dgkz | Diacylglycerol kinase zeta | x | |
| Gabra5 | Gamma-aminobutyric acid (GABA) A receptor, alpha 5 | x | |
| Homer3 | Homer homolog 3 (Drosophila) | x | |
| Itpr1 | Inositol 1,4,5-triphosphate receptor, type 1 | x | |
| Kcnab2 | Potassium voltage-gated channel, shaker-related subfamily, beta member 2 | x | |
| Ksr1 | Kinase suppressor of ras 1 | x | |
| Mpp3 | Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) | x | |
| Neto1 | Neuropilin (NRP) and tolloid (TLL)-like 1 | x | x |
| Nptxr | Chromobox homolog 6; neuronal pentraxin receptor | x | x |
| Pragmin | Pragma of Rnd2 | x | |
| Prickle2 | Prickle homolog 2 (Drosophila) | x | x |
| Rem2 | RAS (RAD and GEM) like GTP binding 2 | x | x |
| Slc17a8 | Solute carrier family 17, member 8 | x | |
| Vav2 | vav 2 guanine nucleotide exchange factor | x | |
| Cacnb2 | Calcium channel, voltage-dependent, beta 2 subunit | x | x |
| Dgka | Diacylglycerol kinase, alpha | x | |
| Hpca | hippocalcin | x | |
| Itpr1 | Inositol 1,4,5-triphosphate receptor, type 1 | x | |
| Prkca | Protein kinase C, alpha | x | |
| Scube2 | Signal peptide, CUB domain, EGF-like 2 | x | |
| Sulf2 | Sulfatase 2 | x |
Genes that are related to Ca2+ binding and synaptic function are indicated.