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. 2017 Dec 12;7:17457. doi: 10.1038/s41598-017-17658-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of elevation differences between successive corneal topography maps recorded before and after elimination of misalignment using ICP algorithm. The analysis was carried out for a randomly-selected KC case (A–D) and a gender- and age-matched (age difference less than 5 years) Normal case (E–H). Contour maps (A,B,E,F) show the elevation differences in the common region of two successive anterior corneal topographies recorded before (A,E) and after (B,F) elimination of misalignment, while contour maps (C,D,G,H) show corresponding elevation differences in the common region of posterior topographies recorded before and after elimination of misalignment. The eight contour maps share the same colour scale (upright in μm). Before ICP correction of misalignment in the KC case, the RMS of fit error was 87.11 μm for both anterior and posterior surfaces, considered simultaneously, and reduced to 52.39 μm following the ICP correction. This can be compared to the Normal case where the RMS of fit error before ICP correction was 9.09 μm for both anterior and posterior surfaces, considered simultaneously, and reduced to 6.64 μm following the ICP correction.