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. 2017 Dec 8;9:409. doi: 10.3389/fnagi.2017.00409

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Copyright © 2017 Lian, Jia, Xu, Zhou, Kang, Liu and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DL0410 decreased the activation of astrocytes and microglia in the hippocampus and cortex. Data are the mean ± SEM (n = 3). DL0410 decreased the expression of glial fibrillary acidic protein (GFAP) and Ionized calcium-binding adapter molecule 1 (Iba-1), and decreased the activation of astrocytes (A) and microglia (B) in the hippocampus and cortex [GFAP: cortex F_(6,14) = 7.660, p = 0.0009, hippocampus F_(6,14) = 4.969, p = 0.0064; Iba-1: cortex F_(6,14) = 8.685, p = 0.0005, hippocampus F_(6,13) = 4.182, p = 0.0146]. Scale bar = 50 μm, and magnification = 400×. ^#p < 0.05, ^##p < 0.01 vs. control group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. model group.