Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 8;9:409. doi: 10.3389/fnagi.2017.00409

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Lian, Jia, Xu, Zhou, Kang, Liu and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effect of DL0410 on inflammation via the RAGE/NF-κB pathway in the hippocampus and cortex. Data are the mean ± SEM (n = 4–6). (A) Representative bands. (B) DL0410 could reduce the expression of RAGE in the hippocampus and cortex (cortex F_(6,17) = 5.012, p = 0.0040, hippocampus F_(6,21) = 5.435, p = 0.0016). (C) DL0410 could decrease the expression of pNF-κB in the hippocampus and cortex (cortex F_(6,28) = 5.234, p = 0.0010, hippocampus F_(6,28) = 7.956, p < 0.0001). (D) DL0410 could decrease the expression of cyclooxygenase-2 (COX2) in the hippocampus and cortex (cortex F_(6,27) = 5.096, p = 0.0013, hippocampus F_(6,16) = 4.438, p = 0.0079). (E) DL0410 could decrease the expression of iNOS in the hippocampus and cortex (cortex F_(6,13) = 2.756, p = 0.0592, hippocampus F_(6,26) = 3.149, p = 0.0186). ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001 vs. control group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. model group.