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. 2017 Dec 8;9:409. doi: 10.3389/fnagi.2017.00409

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Copyright © 2017 Lian, Jia, Xu, Zhou, Kang, Liu and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of DL0410 on the expression of p-JNK, cleaved caspase 3 and cleaved PARP in the hippocampus and cortex. Data are the mean ± SEM (n = 4–6). (A) Representative bands. (B) DL0410 could reduce the expression of p-JNK in the hippocampus and cortex (cortex F_(6,21) = 6.126, p = 0.0008, hippocampus F_(6,19) = 7.427, p = 0.0003). (C) DL0410 could decrease the expression of cleaved caspase 3 in the hippocampus and cortex (cortex F_(6,27) = 2.966, p = 0.0234, hippocampus F_(6,17) = 4.158, p = 0.0094). (D) DL0410 could decrease the expression of cleaved PARP in the hippocampus and cortex (cortex F_(6,18) = 5.087, p = 0.0033, hippocampus F_(6,21) = 18.89, p < 0.0001). (E) DL0410 increased the number of synapse in the hippocampus CA1 area (F_(2,6) = 39.30, p = 0.0004). (magnification: 50,000×, n = 3). ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001 vs. control group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. model group.